Mucinous Adenocarcinoma of the Appendix

Filed under: Mucinous Adenocarcinoma,Mucinous Adenocarcinoma Types - 20 Mar 2013  | Spread the word !

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Mucinous tumors – meaning tumors that produce mucous – of the appendix are quite rare. In normal cases, a thin layer of cells lining the inside of the appendix produce mucous in small amounts. These cells typically die off at the sate rate they reproduce. When tumors occur, the cells reproduce much faster than they die off, creating a mass of cells. These masses of cells are practically the tumors and can produce large amounts of mucous.

There are several types of mucous-producing tumors that can occur in the appendix. These tumors can be either benign or malign. Benign tumors are different from cancerous tumors in the sense that the former don’t usually invade normal tissue or spread to other areas of the body, causing metastasizes. On the other hand, cancerous tumors often do both.

Mucinous adenocarcinoma of the appendix is cancerous, being also the most common type of appendix cancer. Mucinous adenoma, also known as mucinous cystadenoma, is a benign tumor of the appendix. Both types of tumors can release cells into the abdomen and adhere to the inner (peritoneal) surfaces of the abdomen. Some tumor cells may even settle in parts of the abdomen and pelvis. These mucous-producing cells can grow into new tumors and create more mucous.


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Even though they are benign, non-cancerous mucous-producing tumors of the appendix may still be fatal if they grow rapidly or create too much mucous. Therefore, they are referred to as low-grade malignancies when they spread into the abdomen. Very large amounts of thick mucous can be produced by both the benign and the malign types of tumors and can cause the abdomen to become bloated with mucinous ascites. In popular language, this phenomenon is known as “jelly belly”. The large amounts of this thick mucous in the abdomen can eventually squash the organs and cause death.

However, with proper treatment, the prognosis for these benign, low-grade mucous-producing tumors is quite high, the survival outcomes being much better than those of high-grade cancerous tumors of the appendix. Below you can read more about mucinous adenocarcinoma of the appendix, the cancerous type of tumor.

Overview

  • It is the most common cancer of the appendix.
  • It accounts for about 37% of all appendix cancers.
  • It is a high-grade cancerous tumor that produces mucous, but also more commonly invades soft tissues and organs.
  • It may grow faster and is more likely to metastasize (spread) to the lymph nodes, liver and lungs than the low-grade, benign mucinous adenoma.
  • The medical term for extensive spread of these cancerous tumors into the abdomen is Peritoneal Mucinous Carcinomatosis (PMCA) – commonly known as “jelly belly”.

Symptoms

  • Appendicitis is commonly the first symptom of both the benign and cancerous mucous-producing tumor.
  • Both tumors may cause the abdomen to increase in size or form masses in the abdomen or in the pelvis.
  • In men, the first symptom is sometimes an inguinal hernia.
  • In women, the first symptom is often an ovarian mass.

Treatment

  • Treatment for mucinous adenoma that has not ruptured and that is confined to the appendix is removal of the appendix.
  • Treatment for mucinous adenocarcinoma confined to the appendix when the appendix has not ruptured is appendectomy and right hemicolectomy, meaning surgical removal of the appendix and up to half of the right side of the colon.
  • Treatment for mucinous adenocarcinoma that has spread extensively into the abdomen consists of cytoreduction surgery to remove mucous and tumor implants in the abdominal cavity, followed by intraoperative hyperthermic peritoneal chemotherapy. This treatment also applies to benign mucinous tumors.
  • Chemotherapy may also be additionally used for treatment of mucinous adenocarcinoma.


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Risk Factors

  • Mucinous adenocarcinoma of the appendix is most likely to occur in the 6th decade of life, meaning in individuals ages 60 and beyond.

Prognosis

  • Removal of the appendix for mucinous cystadenoma that has not spread is considered curative.
  • Prognosis for both mucinous adenoma and mucinous adenocarcinoma depends on the grade of malignancy of the mucinous tumor and the success of debulking surgeries in removing all tumors that have metastasized into the abdomen.
  • For high-grade mucinous adenocarcinoma that has spread beyond the appendix into the abdomen, 5-year survival has been stated in some studies to be about 50% when treated with surgery combined with chemotherapy.

While mucinous adenocarcinoma can be cured, the most important factor in this condition’s prognosis is the time of diagnosis. The earlier the tumor is detected, the better chances of survival. Remember to do a periodical checkup, especially if you are over 60 and haven’t had the appendix removed.

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All You Should Know About Mucinous Adenocarcinoma Of The Lung

Filed under: Mucinous Adenocarcinoma - 19 Nov 2012  | Spread the word !

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Mucinous cystadenocarcinoma, also known as mucinous adenocarcinoma, of the lung is an extremely rare malignant mucus-producing neoplasm. It is formed by the uncontrolled growth of transformed epithelial cells, which originate in lung tissue.

Mucinous adenocarcinoma is a very rare type of tumor. Actually, only a few dozen cases of this disease have been reported until now in the world. However, specialists have been able to establish a connection between the development of this disease and tobacco smoking, as more than 2/3 of patients have been smokers. Still, the disease has been traced even in people as young as 29.


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Symptoms

One of the most important things that should be mentioned when talking about mucinous adenocarcinoma is that this disease usually causes no symptoms at all. In other words, this form of lung cancer is asymptomatic and is usually found after chest x-rays are taken for other reasons than searching for cancerous tumors.

Actually, lung cancer usually causes no signs and symptoms, at least in the earliest stages. When the cancer starts to grow and advances, symptoms may be experienced. Symptoms of lung cancer will include:

  • Cough;
  • Changes in a chronic cough or smoker’s cough;
  • Coughing up blood;
  • Shortness of breath;
  • Chest pain;
  • Wheezing;
  • Bone pain;
  • Headache;
  • Losing weight with no particular reason.


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Treatment

Treatment for mucinous adenocarcinoma may include numerous options. For instance, specialists may recommend surgery, surgery combined with chemotherapy, chemotherapy or radiation therapy as primary treatments. Treatment will very depending on the seriousness of the disease and the stage in which the condition is diagnosed. Generally, surgery is believed to be the best type of treatment that can be recommended to patients diagnosed with mucinous adenocarcinoma.


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Patients diagnosed with mucinous adenocarcinoma may live more than 10 years without any symptoms or metastasis developed. Statistics indicate a rare overall mortality due to mucinous adenocarcinoma of about 18 to 27 percent. This means that the prognosis for mucinous adenocarcinoma is actually better than for any other form of cancer.

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Advances Are Made For The Treatment Of Colon Cancer

Filed under: Uncategorized - 24 Sep 2012  | Spread the word !

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Colon cancer is the disease starting in the colon, rectum or appendix, associated with anemia and rectal bleeding. This is the third most-common cancer and unfortunately, many times it’s discovered too late to be curable. That is why, research in the domain is very important and doctors take it seriously. And as soon as they have news and information, they are open in sharing it, in over to educate the population on the risks that colon cancer brings with it. The importance of discovering this disease in time is always emphasized and day by day, more and more advances are being made in this medical field.

For your own information, it would be great if you would dedicate just 5 minutes in order to listen Doctor Richard Goldberg talk on the topic. He is a clinical researcher at NC-CH and offers great insights on the recent discoveries made in what concerns colon cancer. Here is the video:

Colon cancer can affect anyone, this is why it’s better to be informed and to know how you can detect this disease in time. Famous people that had it were Ronald Reagan, former Bee Gees member Robin Gibb and Pope John Paul II. Learn about this illness and make sure that if something happens to you, you can get cured.

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The Incidence Of Patients With Mucinous Adenocarcinoma In Singapore

Filed under: Studies - 29 May 2012  | Spread the word !

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The mucinous adenocarcinoma is a type of cancer. This cancer begins in cells that line internal organs and produce mucin. Mucin is the main component of mucus. This cancer also includes various types, because it can be localized in certain organs inside the human body. Usually, for a patient with such a diagnosis, the survival hope can be up to 10 years, if the invasion is absent. For 90% of the cancer patients that did not suffered invasion, the survival is ensured. In the first half of the 2000s, a study regarding this type of cancer was made in an Asian country. The description of the study and also its results were published in 2004. Because there was not sufficient data regarding the incidence of cancer in Asians, the population of this specific country was chosen on purpose to avoid bias. The goal of the study was to obtain clear results and after weighting upon which country should be the one included, Singapore was the one that was finally chosen.
The data used for the study of the incidence of this type of cancer was taken from the Singapore Registry. Since 1968 and until 1997, from a total of 15,762 cases of cancer in this Asian country, 627 were mucinous cancer cases. The patients had colorectal cancer and their personal data was used to see the incidence of this type of cancer and the survival rate of these patients in comparison with classical hazards model. The study showed that the incidence rate of this cancer remained the same through the years for males, but was rising in two periods for females. From 1968 to 1972 and from 1993 to 1997, the incidence of this type of carcinoma of the colon and rectum had easily risen. Comparing genders, the proportions were similar. 
Comparing age groups in this study about mucinous adenocarcinoma, it was discovered that this cancer was more frequent in the younger age groups. For most of the patients with colon cancer, there was an approximately five year survival rate, while for those with rectum cancer, the rates were lower. The results of the study led to the conclusions that rectum cancer is much more aggressive than colon cancer, while differences which appeared between Malaysian patients and Indian patients living in Singapore proved that this type of cancer can affect some ethnicities more than others.

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Mucinous Adenocarcinoma of the Colon and Rectum

Filed under: Uncategorized - 30 Mar 2012  | Spread the word !

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The term adenocarcinoma refers to malignancy of the epithelial tissue, so it means that it is a cancer which starts in the epithelial tissue. The word ‘adeno’ means gland, and ‘carcinoma’ is a malignant tumor. The term ‘mucinus’ refers to something that has a lot of mucus. Put these terms together and you get mucinous adenocarcinoma, which therefore means a type of adenocarcinoma which contains 60% or more mucus in it. Mucinous adenocarcinoma of the colon and rectum is one of the most common types of colorectal cancers. Researches have shown that up to 95% of the colorectal cancers are mucinous adenocarcinoma.

Researchers have linked the presence of mucus to the faster spreading of cancer cells. Therefore, mucinous adenocarcinoma is one of the most aggressive types of cancer and its treatment is rarely successful. Mucinous adenocarcinoma attacks the glands in the body, both the exocrine and the endocrine ones. Moreover, nearly any extra cells growth in the glands can develop into mucinous adenocarcinoma. If the tumor is formed in the colo-rectal area, the better are the chances of it developing into cancer. mucinous adenocarcinoma resemble polyps and has a gelatinous nature, therefore it is very difficult to treat. Not to mention the fact that mucinous adenocarcinoma can show no or little symptoms in its earliest stages and it can even go undetected for years, even if the polyps have been there for a very long time.

There are three main methods of treating mucinous adenocarcinoma: chemotherapy, radiation therapy, and laparoscopic surgery. Individuals diagnosed with mucinous adenocarcinoma will most likely need a combination of these methods, depending on the position and size of the tumor. Laparoscopic surgery implies the removal of the tumor by surgical method, which is minimal invasive. After the surgery, the patient will probably need to undergo chemotherapy or radiation therapy, or maybe a combination between those two, in order to get more successful results. Nevertheless, the doctors will know which course of treatment is best to approach. However, as mucinous adenocarcinoma is often caught too late, its prognosis is not very bright.

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Facts About Mucinous Adenocarcinoma Of The Appendix

Filed under: Uncategorized - 23 Aug 2011  | Spread the word !

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Mucinous adenocarcinoma of the appendix is a rare condition, but there are still cases in which it can be diagnosed. The cases of mucinous adenocarcinoma of the appendix are thought to be uncommon, but unfortunately people can experience a condition of this kind. Mucinous adenocarcinoma is usually formed when thin layer of cells produce mucous in higher quantities, creating a mass of cells. Cells divide and die quicker, determining large amounts of mucous. Such a development is of course going to be found at the appendix level.

Well, the problem seems to be that when mucinous adenocarcinoma of the appendix is being found, they can determine the death of the patient diagnosed with such a condition. Anyway, when referring to mucinous adenocarcinoma, the tumors created can be benign or cancerous, determining appendix cancer. When the tumor diagnosed at the patient suffering from mucinous adenocarcinoma of the appendix is benign, the cancer will not commonly spread to other parts of the body.

Mucinous adenocarcinoma of the appendix can be fatal and the main thing that explains that reality is that the tumors grow very quick and they can easily be spread throughout the body. Most types of cancers create metastases and that means they spread from the location where the initial tumor has been formed, to other organs in the body, and when referring to mucinous adenocarcinoma of the appendix, metastases are usually formed on the lymph nodes, the liver or the lungs. When cancer, regardless of its type, starts spreading the disease is very hard to cure, in many cases finding a treatment to work being actually impossible. This is why getting the proper diagnosis as soon as the condition is being formed is very important. Being attentive at the symptoms will be a way on your road to get an early diagnosis. Symptoms will most commonly include anemia, fever and abdominal pain. Treatment for mucinous adenocarcinoma will usually include a series of medications, but the doses and the basic elements that form the treatment will vary from one individual to another.

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Mucinous Adenocarcinoma Facts

Filed under: Uncategorized - 12 Nov 2010  | Spread the word !

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Cancer is a reality that many of use have to deal with in life, as the percentage of people getting cancer seems always to be on the rise. Even when lung cancer statistics get lower other forms of organ or body cancers appear to rise because of lifestyle habits, drinking, smoking and other related topics like pesticides on foods. The term mucinous adenocarcinoma is one that is commonly used to define one particular type of cancerous growth. This type of cancer is defined by the large amount of mucus that is produced by the cancerous cells. The mucus is said to make the cancer grow more rapidly however this is not 00% certain.

By breaking down the word mucinous adenocarcinoma this will help you to reveal the meaning of the word as a whole. Firstly we have already discussed the mucinous part of this particular type of cancer, which makes it an even more dangerous type. The word adeno is specific to certain parts of the body, the internal glands and other organs. Carcinoma is a word to describe cancer cells that are present in the body. If we were able to use Stem cell research to reverse the effects of the cancerous growth then we might be able to stop the growth in its tracks however at this stage there is still no cure for cancer except for removal of the cancerous tissue, which can often result in the death of the patient.

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Mucinous Adenocarcinoma of the Lung

Filed under: Uncategorized - 21 Sep 2010  | Spread the word !

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Mucinous Adenocarcinoma of the lung is a tumor of the lung. This tumor either floats in pools of mucus or line the alveolar walls of the lung. This tumor is the type of lung tumor most closely associated with patients who did not spend a lifetime smoking.

Adenocarcinoma cancer is made of cancer cells that develop in the lining of all internal organs. Though it is most often associated with the lung, it can also develop in the stomach, colon, prostate and pancreas, to just name a few.

Mucinous Adenocarcinoma has many different treatment options. Those who are diagnosed with it can undergo surgery, radiation, immunotherapy or chemotherapy. All of these options yield different results and are specifically tailored to each patient and his individual cancer in order to lead to the best possible results.

There are also many new therapies that are still undergoing testing. Getting involved in one of the trails is an exciting way to combat your cancer and also help the scientific community better understand it and how to fight it. Some of the new treatment options being tested are hormone therapy, stem cell transplantation, chemoembolization and photodynamic therapy. All of these therapies are completely optional and it is up to the patient to decide if he wants to participate.

Mucinous Adenocarcinoma is one of the most common lung cancers diagnosed in the United States. Finding a hospital that offers a good treatment plan near you is the first step toward battling this cancer and moving on with your life.

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Mucinous Adenocarcinoma of the Appendix

Filed under: Uncategorized - 12 Jul 2010  | Spread the word !

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Here's what this is all about…mucinous adenocarcinoma of the appendix are rare and uncommon. What typically happens is a that a thin layer of cells line the inside of the appendix, creating mucous in tiny amounts. These particular cells usually die off at a time that is equivalent to their reproduction. When it comes to tumors, the cells multiply quicker than they die of. This causes a mass creation of cells. By the same token, these masses of cells, known as tumors, bring about enormous amounts of mucous.

The simple fact of the matter is that there are several dissimilar mucous-producing tumors that can show up in the appendix. That said, they can be both cancerous mucous-producing tumors in addition to benign mucous-producing tumors. Mucinous adenocarcinoma of the appendix is a tumor that is cancerous and is the most common kind of appendix cancer. The low-grade, benign tumor in the appendix is known as Mucinous Adenoma or Mucinous Cystadenoma.

With a benign tumor, it won't invade normal tissue, spreading to other areas of the body. Tumors deemed cancerous will do both – attack normal tissue and spread to other areas of the body. Mucinous adenocarcinoma of the appendix can turn out to be fatal because of the very huge amounts of thick mucous being produced. Because it grows so quickly, it is more than likely to spread to the lymph nodes, the liver, and the lungs. Treatment, when confined to the appendix and it has not ruptured is appendectomy and right hemicolectomy (removal of half of the right side of the colon.)

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Survival Prognosis of Mucinous Adenocarcinoma of the Appendix

Filed under: Uncategorized - 22 Feb 2010  | Spread the word !

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Mucinous adenocarcinoma of the Appendix accounts for a little over a third of all cancers of the appendix. The tumor cells produce a mucous that scientists believe makes the tumor more aggressive so it spreads faster than a nonmucinous tumor.

But there is not a lot known about whether individuals who have a mucinous adenocarcinoma of the appendix have a worse prognosis as compared to those who have nonmucinous tumors of the appendix.

A study was done in 2008 in Taiwan looked at 34 patients with mucinous and nonmucinous adenocarcinomas of the appendix. The goal of the study was to determine if there was a difference in survival between patients that had mucinous and nonmucinous adenocarcinoma of the appendix. The information on each patient that was collected included: the signs and symptoms they had, the diagnosis made prior to surgery, the type of surgical procedure that was performed (curative or noncurative resection), what was observed during surgery, if the tumor could be removed, the tumor type (mucinous or nonmucinous), and if they had chemotherapy.

It was found that symptoms such as anemia, fever/chills, abdominal pain, and abdominal masses found upon examination occurred at the same rate in patients who had nonmucinous and mucinous adenocarcinomas of the appendix. The only clinical sign that was different between the groups was there more patients with nonmucinous tumors had higher white blood cell counts than those with mucinous tumors.

Patients from both groups who had a curative resection had the same prognosis. Individuals with mucinous adenocarcimona who had a noncurative resection had a better prognosis compared to individuals with nonmucinous adenocarcinoma of the appendix. This is interesting since scientists believe the mucous in the mucinous adenocarcinomas makes the tumors more aggressive.

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